Extensive Exon Reshuffling Over Evolutionary Time Coupled to Trans-Splicing in Drosophila
نویسندگان
چکیده
منابع مشابه
Extensive exon reshuffling over evolutionary time coupled to trans-splicing in Drosophila.
The relative position of exons in genes can be altered only after large structural mutations. These mutations are frequently deleterious, impairing transcription, splicing, RNA stability, or protein function, as well as imposing strong inflexibility to protein evolution. Alternative cis- or trans-splicing may overcome the need for genomic structural stability, allowing genes to encode new prote...
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ژورنال
عنوان ژورنال: Genome Research
سال: 2003
ISSN: 1088-9051
DOI: 10.1101/gr.1440703